Damaged Cells Are Highly Mobile But Lack Direction
Cells on the move reach forward with lamellipodia and filopodia, cytoplasmic sheets and rods supported by branched networks or tight bundles of actin filaments. Cells without functional lamellipodia are still highly motile but lose their ability to stay on track, report researchers at the Stowers Institute for Medical Research in today’s online issue of the Journal of Cell Biology.
Their study provides new insight into cell motility, a complex and integrated process, which, when gone awry, can lead to various disease conditions such as cancer metastasis, birth defects, cardiovascular disease and compromised immune function.
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